The human papilloma virus oncoprotein E7 degrades the retinoblastoma protein by enhancing calpain activity

子宫颈癌是世界上第二大流行癌症，也是妇女癌症死亡的第五大原因。每年确诊的新病例约为47万例。在大多数情况下，宫颈癌被认为是由某些类型的人乳头瘤病毒引起的。人类乳头瘤病毒制造一系列蛋白质，这些蛋白质会破坏它们感染的细胞中的关键宿主蛋白质。这种破坏是子宫颈癌形成的关键。我们最近发现，我们可以利用钙蛋白酶抑制剂阻止这种破坏并挽救关键的宿主蛋白。在这里，我们试图确定钙蛋白酶抑制剂是否可以在治疗人乳头瘤病毒相关癌症中找到应用。

Cervical cancer is the second most prevalent cancer worldwide and the fifth leading cause of cancer deaths in women. Approximately 470,000 new cases are diagnosed annually. In most cases cervical cancer is thought to be caused by certain types of the human papillomavirus. Human papillomavirus makes a seies of proteins that cause the destruction of key host proteins in the cells they infect. This destruction is central to the formation of cervical cancer. We have recently discovered that we can prevent this destruction and rescue the key host proteins using inhibitors of the enzyme calpain. Here we seek to determine whether calpain inhibitors could find application in the treatment of human papillomavirus associated cancer.