The human papilloma virus oncoprotein E7 degrades the retinoblastoma protein by enhancing calpain activity

人乳头瘤病毒癌蛋白 E7 通过增强钙蛋白酶活性来降解视网膜母细胞瘤蛋白

• 批准号: nhmrc : 389805
• 负责人: Dr Grant Darnell
• 金额: $ 17.21万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/human-papilloma-virus-calpain-activity/97087
• 关键词: human; papilloma; virus; oncoprotein; E7

Cervical cancer is the second most prevalent cancer worldwide and the fifth leading cause of cancer deaths in women. Approximately 470,000 new cases are diagnosed annually. In most cases cervical cancer is thought to be caused by certain types of the human papillomavirus. Human papillomavirus makes a seies of proteins that cause the destruction of key host proteins in the cells they infect. This destruction is central to the formation of cervical cancer. We have recently discovered that we can prevent this destruction and rescue the key host proteins using inhibitors of the enzyme calpain. Here we seek to determine whether calpain inhibitors could find application in the treatment of human papillomavirus associated cancer.

宫颈癌是全球第二大常见癌症，也是女性癌症死亡的第五大原因。每年诊断出大约 470,000 例新病例。在大多数情况下，宫颈癌被认为是由某些类型的人乳头瘤病毒引起的。人乳头瘤病毒产生一系列蛋白质，导致其感染的细胞中关键宿主蛋白质被破坏。这种破坏对于宫颈癌的形成至关重要。我们最近发现，我们可以使用钙蛋白酶抑制剂来防止这种破坏并拯救关键的宿主蛋白。在这里，我们试图确定钙蛋白酶抑制剂是否可以用于治疗人乳头瘤病毒相关的癌症。