NEW INSIGHTS INTO THE FUNCTION OF SERPINB2

对 SerPINB2 功能的新见解

• 批准号: nhmrc : 442952
• 负责人: Dr Grant Darnell
• 金额: $ 34.27万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-insights-function-serpinb2/96936
• 关键词: NEW; INSIGHTS; INTO; FUNCTION; SERPINB2

Plasminogen activator inhibitor type 2 (PAI-2) or SerpinB2 is a protein that has been extensively studied in the field of cancer prognosis and inflammation. Although it is widely believed that this protein exists outside the cell and inhibits enzymes involved in blood clotting and cell migration, it is becoming increasingly clear that this may not be its primary function. We have identified two important new functions for this protein that are related to activities within the cell. These activities involve regulation of cellular growth and resistence to viral infections. This grant seeks to characterise these different activities and determine how they affect cell behaviour and thereby determine the real role of this protein. Understanding what this protein actually does will have implications for understanding cancer prognosis and antiviral resistance.

纤溶酶原激活物抑制剂2型（派-2）或SerpinB 2是一种在癌症预后和炎症领域得到广泛研究的蛋白质。尽管人们普遍认为这种蛋白质存在于细胞外，并抑制与血液凝固和细胞迁移有关的酶，但越来越清楚的是，这可能不是它的主要功能。我们已经确定了这种蛋白质的两个重要的新功能，它们与细胞内的活动有关。这些活动涉及调节细胞生长和抵抗病毒感染。这项资助旨在研究这些不同的活动，并确定它们如何影响细胞行为，从而确定这种蛋白质的真实的作用。了解这种蛋白质的实际作用将对了解癌症预后和抗病毒耐药性产生影响。