NEW INSIGHTS INTO THE FUNCTION OF SERPINB2

纤溶酶原激活物抑制剂2型（PAI-2）或SerpinB2是一种在癌症预后和炎症领域被广泛研究的蛋白。尽管人们普遍认为这种蛋白质存在于细胞外，并抑制参与血液凝固和细胞迁移的酶，但越来越清楚的是，这可能不是它的主要功能。我们已经确定了这种蛋白质的两个重要的新功能，它们与细胞内的活动有关。这些活动包括调节细胞生长和抵抗病毒感染。这项资助旨在描述这些不同的活动，并确定它们如何影响细胞行为，从而确定这种蛋白质的真正作用。了解这种蛋白质的实际作用将有助于了解癌症预后和抗病毒药物耐药性。

Plasminogen activator inhibitor type 2 (PAI-2) or SerpinB2 is a protein that has been extensively studied in the field of cancer prognosis and inflammation. Although it is widely believed that this protein exists outside the cell and inhibits enzymes involved in blood clotting and cell migration, it is becoming increasingly clear that this may not be its primary function. We have identified two important new functions for this protein that are related to activities within the cell. These activities involve regulation of cellular growth and resistence to viral infections. This grant seeks to characterise these different activities and determine how they affect cell behaviour and thereby determine the real role of this protein. Understanding what this protein actually does will have implications for understanding cancer prognosis and antiviral resistance.