SERPINB2 IS AN INDUCIBLE HOST FACTOR INVOLVED IN ENHANCING HIV-1 TRANSCRIPTION AND REPLICATION

SERPINB2 是一种可诱导的宿主因子，参与增强 HIV-1 转录和复制

• 批准号: nhmrc : 442951
• 负责人: Dr Grant Darnell
• 金额: $ 33.1万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/serpinb2-an-inducible-transcription-replication/101530
• 关键词: SERPINB2; INDUCIBLE; HOST; FACTOR; INVOLVED

SerpinB2 is one of the most abundant proteins made at sites of inflammation. We have shown that HIV-1 infection also induces SerpinB2 and that SerpinB2 then helps the virus to replicate. In this grant we seek to understand how the virus causes this protein to be made and how this protein then increases virus replication. In the human population there are different forms of SerpinB2 and this grant seeks to determine whether these different forms affect HIV-1 replications differently. It may for instance be possible that an individual who has a certain form of SerpinB2 may be less susceptable to AIDS following HIV-1 infection.

SerpinB2 是炎症部位产生的最丰富的蛋白质之一。我们已经证明，HIV-1 感染也会诱导 SerpinB2，然后 SerpinB2 会帮助病毒复制。在这笔资助中，我们试图了解病毒如何产生这种蛋白质，以及这种蛋白质如何增加病毒复制。人类中有不同形式的 SerpinB2，这项资助旨在确定这些不同形式是否对 HIV-1 复制产生不同的影响。例如，具有某种形式的 SerpinB2 的个体在感染 HIV-1 后可能不太容易感染艾滋病。