SERPINB2 IS AN INDUCIBLE HOST FACTOR INVOLVED IN ENHANCING HIV-1 TRANSCRIPTION AND REPLICATION

SerpinB2是炎症部位产生的最丰富的蛋白质之一。我们已经证明，HIV-1感染也会诱导SerpinB2，然后SerpinB2帮助病毒复制。在这笔赠款中，我们试图了解病毒如何导致这种蛋白质的产生，以及这种蛋白质如何促进病毒复制。在人类群体中，有不同形式的SerpinB2，这项赠款旨在确定这些不同形式是否以不同方式影响HIV-1复制。例如，在感染HIV-1后，具有某种形式的SerpinB2的个人可能不太容易感染艾滋病。

SerpinB2 is one of the most abundant proteins made at sites of inflammation. We have shown that HIV-1 infection also induces SerpinB2 and that SerpinB2 then helps the virus to replicate. In this grant we seek to understand how the virus causes this protein to be made and how this protein then increases virus replication. In the human population there are different forms of SerpinB2 and this grant seeks to determine whether these different forms affect HIV-1 replications differently. It may for instance be possible that an individual who has a certain form of SerpinB2 may be less susceptable to AIDS following HIV-1 infection.