The Hunt for New-generation Lipopeptide Antibiotics Targeting Gram-negative ‘Superbugs’

寻找针对革兰氏阴性菌“超级细菌”的新一代脂肽抗生素

• 批准号: nhmrc : 1086825
• 负责人: Dr Tony Velkov
• 金额: $ 31.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hunt-new-generation-negative-superbugs/519150
• 关键词: Hunt; New; generation; Lipopeptide; Antibiotics

The dry antibiotic discovery and development pipeline, together with the increasing incidence of bacterial resistance in the clinic has been dubbed ‘the perfect storm’. This project involves the design, synthesis and preclinical evaluation of a new generation of polymyxin-like lipopeptides that have low nephrotoxicity and specifically target polymyxin-resistant Gram-negative ‘superbugs’.

枯燥的抗生素发现和开发流程，加上临床上不断增加的细菌耐药性发生率，被称为“完美风暴”。该项目涉及新一代多粘菌素样脂肽的设计、合成和临床前评估，该脂肽具有低肾毒性，并专门针对多粘菌素耐药的革兰氏阴性“超级细菌”。