The identification of channel-like tranport pathways in the malaria-infected erythrocyte using animal peptide toxins.

使用动物肽毒素鉴定感染疟疾的红细胞中的通道样转运途径。

• 批准号: nhmrc : 1016839
• 负责人: Dr Richard Allen
• 金额: $ 29.28万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-channel-like-peptide-toxins/109811
• 关键词: identification; channel; like; tranport; pathways

Malaria is a serious infectious disease caused by a parasite uniquely adapted to live inside the red cells of its human host. The parasite alters its host cell by creating distinctive transport pathways in the cell membrane. Important to parasite survival, the identities of these pathways are unknown. Animal toxins, among other methods, will be used to identify and characterise these pathways. We aim to understand more about their function, and thereby to develop novel treatments.

疟疾是一种严重的传染病，由一种寄生虫引起，这种寄生虫特别适合生活在人类宿主的红细胞内。这种寄生虫通过在细胞膜上创造独特的运输途径来改变其宿主细胞。重要的寄生虫生存，这些途径的身份是未知的。除其他方法外，动物毒素将用于识别和鉴定这些途径。我们的目标是更多地了解它们的功能，从而开发新的治疗方法。