The immune modulatory function of chondroitin sulphate A in placental malaria: protecting the fetus, promoting the parasite?

硫酸软骨素 A 在胎盘疟疾中的免疫调节功能：保护胎儿，促进寄生虫？

• 批准号: nhmrc : 1065696
• 负责人: A/Pr Joanne Said
• 金额: $ 35.29万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-modulatory-function-promoting-parasite/455190
• 关键词: immune; modulatory; function; chondroitin; sulphate

Pregnant women and their babies are susceptible to placental malaria infection. Malaria parasites infect the placenta by binding to chondroitin sulfate A (CSA). CSA levels increase in normal pregnancy. Studies suggest that CSA can suppress immune cell function. This study will look at the immune modulating function of CSA during pregnancy and placental malaria. CSA may act as camouflage, hiding the malaria parasite from immune cells. This may be a novel immune evasion pathway.

孕妇及其婴儿容易感染胎盘疟疾。疟疾寄生虫通过结合硫酸软骨素A(CsA)感染胎盘。CsA水平在正常妊娠时升高。研究表明，CsA可以抑制免疫细胞功能。这项研究将着眼于CsA在妊娠和胎盘疟疾期间的免疫调节功能。CsA可以起到伪装的作用，将疟疾寄生虫隐藏起来，使其不被免疫细胞发现。这可能是一种新的免疫逃避途径。