Measuring hypoxia induced mRNA in maternal blood to monitor wellbeing of growth-restricted fetuses

测量母血中缺氧诱导的 mRNA 以监测生长受限胎儿的健康状况

• 批准号: nhmrc : 1028521
• 负责人: A/Pr Joanne Said
• 金额: $ 28.1万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/measuring-hypoxia-induced-restricted-fetuses/110642
• 关键词: Measuring; hypoxia; induced; mRNA; maternal

Severely growth restricted fetuses are at peril of stillbirth from low oxygenation. While ultrasound monitoring improves outcomes, babies are still lost. Better ways to monitor the health the unborn baby are needed. We have recently discovered fetuses’ starved of oxygen leak RNA into mother's blood. Thus, measuring RNA molecules in blood could be used to assess fetal health. We will examine whether measuring mRNA in maternal blood could be used to monitor wellbeing of growth-restricted fetuses.

严重生长受限的胎儿有因低氧而死产的危险。虽然超声波监测可以改善结局，但婴儿仍然会走失。需要更好的方法来监测未出生的婴儿的健康。我们最近发现，胎儿缺氧会将RNA泄漏到母亲的血液中。因此，测量血液中的RNA分子可以用来评估胎儿健康。我们将研究测量母亲血液中的mRNA是否可以用来监测生长受限胎儿的健康状况。