The impact of granzyme B on cytotoxic T cell migration through tissue

细胞毒性T细胞（CTL）是白色血细胞，其以协调的方式移动到身体组织中以靶向并破坏病毒感染的细胞或癌细胞。当这些异常细胞摄取CTL释放的细胞毒性酶（蛋白酶）时，它们就会被破坏。我们提出，这些细胞毒素之一，颗粒酶B，具有双重功能，它也参与帮助CTL有效地向靶细胞移动，通过清除一个路径，通过当地的组织结构。

Cytotoxic T cells (CTL) are white blood cells that move in an orchestrated way into body tissues to target, and destroy, virus-infected or cancer cells. Destruction of these abnormal cells is achieved when they ingest cytotoxic enzymes (proteases) released by CTL. We propose that one of these cytotoxins, granzyme B, has a dual function, and that it is also involved in helping CTL to efficiently move towards the target cells by clearing a path through the local tissue structure.