The impact of granzyme B on cytotoxic T cell migration through tissue

颗粒酶 B 对细胞毒性 T 细胞通过组织迁移的影响

• 批准号: nhmrc : 1007830
• 负责人: Dr Paulus Mrass
• 金额: $ 40.41万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-granzyme-b-migration-tissue/109251
• 关键词: impact; granzyme; cytotoxic; cell; migration

Cytotoxic T cells (CTL) are white blood cells that move in an orchestrated way into body tissues to target, and destroy, virus-infected or cancer cells. Destruction of these abnormal cells is achieved when they ingest cytotoxic enzymes (proteases) released by CTL. We propose that one of these cytotoxins, granzyme B, has a dual function, and that it is also involved in helping CTL to efficiently move towards the target cells by clearing a path through the local tissue structure.

细胞毒性 T 细胞 (CTL) 是一种白细胞，它们以精心策划的方式移动到身体组织中，以瞄准并摧毁病毒感染的细胞或癌细胞。当这些异常细胞摄入 CTL 释放的细胞毒性酶（蛋白酶）时，它们就会被破坏。我们提出，这些细胞毒素之一颗粒酶 B 具有双重功能，它还参与通过清理局部组织结构的路径来帮助 CTL 有效地移向靶细胞。