Mechanisms of T cell migration and interactions in tumours

肿瘤中 T 细胞迁移和相互作用的机制

• 批准号: nhmrc : 512265
• 负责人: Dr Paulus Mrass
• 金额: $ 40.63万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-t-cell-interactions-tumours/83102
• 关键词: Mechanisms; cell; migration; interactions; tumours

Cancer is still a leading cause of death. Thus, there is great need to develop improved anti-cancer therapies, which could be achieved by boosting the body's own resources, i.e. the immune system. Using a functional imaging approach, i.e. two-photon microscopy, we will directly visualise how tumour cells are attacked by the immune system. Mechanistic insight into this process will serve as a basis for the development of improved immuno-therapeutic strategies that aim to target cancer cells.

癌症仍然是主要的死亡原因。因此，非常需要开发改进的抗癌疗法，这可以通过增强人体自身资源，即免疫系统来实现。使用功能成像方法，即双光子显微镜，我们将直接可视化肿瘤细胞如何受到免疫系统的攻击。对这一过程的机械性洞察将成为开发以癌细胞为靶点的改进免疫治疗策略的基础。