The impact of the identification and inclusion of acceptable HLA-mismatches on the transplant potential of highly-sensitised renal transplant candidates.

识别和纳入可接受的 HLA 错配对高度敏感的肾移植候选者的移植潜力的影响。

• 批准号: nhmrc : 1056420
• 负责人: Dr Hung Do Nguyen
• 金额: $ 6.69万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-identification-inclusion-transplant-candidates/112555
• 关键词: impact; identification; inclusion; acceptable; HLA

In Australia, allocation of donor kidneys are currently weighted largely on the degree of donor-recipient HLA compatibility. However, not all HLA mismatches leads to negative outcomes. Acceptable HLA-mismatches are antigen mismatches that can be considered compatible at a structural and functional level and have been applied to circumvent the problem of difficulty finding suitable donors for highly-sensitised transplant candidates. We apply this concept to the Australian kidney transplant population.

在澳大利亚，供者肾脏的分配目前很大程度上取决于供者与受者的人类白细胞抗原相容程度。然而，并不是所有的HLA错配都会导致负面结果。可接受的人类白细胞抗原不匹配是指在结构和功能水平上可以被认为是相容的抗原不匹配，已经被应用于绕过为高度敏感的移植候选者难以找到合适的捐赠者的问题。我们将这一概念应用于澳大利亚的肾移植人群。