The link between regional lung stretch and distal organ injury in response to mechanical ventilation

机械通气引起的局部肺拉伸与远端器官损伤之间的联系

• 批准号: nhmrc : GNT1160774
• 金额: $ 73.26万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/link-regional-lung-mechanical-ventilation/1379143
• 关键词: link; between; regional; lung; stretch

Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have very high mortality rates (over 30%). Unfortunately, mechanical ventilation, a life-saving intervention contributes to this high mortality. Interestingly, very few of these critically ill patients die from a lack of oxygen with the vast majority dying from 'non-lung' organ failure. In this study we will investigate the mechanisms linking mechanical ventilation with organ failure with a view to improving mortality.

急性呼吸窘迫综合征（ARDS）和急性肺损伤（ALI）的死亡率很高（超过30%）。不幸的是，机械通气，一种挽救生命的干预措施导致了这种高死亡率。有趣的是，这些重症患者中很少有人死于缺氧，绝大多数死于“非肺”器官衰竭。在这项研究中，我们将探讨机械通气与器官衰竭的机制，以期提高死亡率。