The link between regional lung stretch and distal organ injury in response to mechanical ventilation

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Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have very high mortality rates (over 30%). Unfortunately, mechanical ventilation, a life-saving intervention contributes to this high mortality. Interestingly, very few of these critically ill patients die from a lack of oxygen with the vast majority dying from 'non-lung' organ failure. In this study we will investigate the mechanisms linking mechanical ventilation with organ failure with a view to improving mortality.