Antigen recognition by CD1a-restricted T cells in the human immune system

人体免疫系统中 CD1a 限制性 T 细胞对抗原的识别

• 批准号: nhmrc : GNT1122890
• 负责人: Dr Adam Uldrich
• 金额: $ 61.55万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antigen-recognition-cd1a-human-immune/1347305
• 关键词: Antigen; recognition; CD1a; restricted; cells

Human immunity requires protective T cells that target foreign molecules for removal. Even though substantial populations of T cells exist that recognise lipid molecules, little is known about their basic biology. We will identify and characterise lipid reactive human T cells and examine their response to foreign or self-lipids expressed by infectious organisms and host cells. This work will have important implications in understanding lipid reactive T cells in health and disease.

人免疫需要针对外国分子去除的保护性T细胞。即使存在识别脂质分子的大量T细胞群，对它们的基本生物学知之甚少。我们将识别和表征脂质反应性人T细胞，并检查其对由传染性生物和宿主细胞表达的外脂或自脂的反应。这项工作将对了解健康和疾病中的脂质反应性T细胞具有重要意义。