Butyrophilin ligand sensing by the immune system

免疫系统检测嗜乳酪蛋白配体

• 批准号: DP230102753
• 负责人: Dr Adam Uldrich
• 金额: $ 26.72万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102753
• 关键词: Butyrophilin; ligand; sensing; immune; system

T cells are an important part of the immune system, surveying our body and preventing many diseases. A subset of T cells, gamma delta T cells, are a crucial component of the immune system. A key problem is that the mechanism(s) controlling gamma delta T cell behaviour are poorly understood. This proposal aims to decode how these cells are triggered into action by using innovative tools to investigate the molecular basis underpinning their function. This project expects to create fundamental new knowledge regarding how gamma-delta T cells are regulated, which will ultimately allow us to harness these cells to improve health.

T细胞是免疫系统的重要组成部分，调查我们的身体并预防许多疾病。 T细胞的子集，伽马三角细胞是免疫系统的关键组成部分。一个关键问题是，控制伽马三角细胞行为的机制知之甚少。该建议旨在通过使用创新工具研究其功能的分子基础来解码如何将这些细胞触发到作用中。该项目预计将创建有关如何调节伽马 - 戴尔塔T细胞的基本新知识，这最终将使我们利用这些细胞改善健康。