Butyrophilin ligand sensing by the immune system

免疫系统检测嗜乳酪蛋白配体

• 批准号: DP230102753
• 负责人: Dr Adam Uldrich
• 金额: $ 26.72万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102753
• 关键词: Butyrophilin; ligand; sensing; immune; system

T cells are an important part of the immune system, surveying our body and preventing many diseases. A subset of T cells, gamma delta T cells, are a crucial component of the immune system. A key problem is that the mechanism(s) controlling gamma delta T cell behaviour are poorly understood. This proposal aims to decode how these cells are triggered into action by using innovative tools to investigate the molecular basis underpinning their function. This project expects to create fundamental new knowledge regarding how gamma-delta T cells are regulated, which will ultimately allow us to harness these cells to improve health.

T细胞是免疫系统的重要组成部分，负责监测我们的身体并预防许多疾病。T细胞的一个子集，γ δ T细胞，是免疫系统的重要组成部分。一个关键问题是，控制γ δ T细胞行为的机制知之甚少。该提案旨在通过使用创新工具来研究支持其功能的分子基础，来解码这些细胞是如何被触发的。该项目预计将创造关于γ-δ T细胞如何调节的基本新知识，这将最终使我们能够利用这些细胞来改善健康。