Apoptotic cell clearance: from basic biology to new therapeutic strategies for chronic respiratory disease

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The controlled death and replacement of cells in our bodies is critical for healthy physiology, development and resolving of inflammation. Many cells can ‘eat’ other cells, and normally dead/dying cells are rapidly removed. Defects in this process contribute to chronic inflammation and disease. We aim to develop new drugs that enhance dead cell clearance, to better understand how it works and offer a new therapeutic approach for chronic inflammatory lung diseases of emphysema, COPD and asthma.