Apoptotic cell clearance: from basic biology to new therapeutic strategies for chronic respiratory disease

凋亡细胞清除：从基础生物学到慢性呼吸道疾病的新治疗策略

• 批准号: nhmrc : GNT1159582
• 负责人: Dr Caitlin Gillis
• 金额: $ 41.72万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/apoptotic-cell-clearance-respiratory-disease/1349300
• 关键词: Apoptotic; cell; clearance; basic; biology

The controlled death and replacement of cells in our bodies is critical for healthy physiology, development and resolving of inflammation. Many cells can ‘eat’ other cells, and normally dead/dying cells are rapidly removed. Defects in this process contribute to chronic inflammation and disease. We aim to develop new drugs that enhance dead cell clearance, to better understand how it works and offer a new therapeutic approach for chronic inflammatory lung diseases of emphysema, COPD and asthma.

我们体内细胞的受控死亡和替换对于健康的生理学，炎症的发展和解决至关重要。许多细胞可以“吃掉”其他细胞，通常死亡/垂死的细胞会被迅速清除。这个过程中的缺陷会导致慢性炎症和疾病。我们的目标是开发新的药物，增强死细胞清除，以更好地了解它是如何工作的，并提供一种新的治疗方法，慢性炎症性肺疾病的肺气肿，慢性阻塞性肺病和哮喘。