Defining the molecular regulators of apoptotic cell disassembly and their role in cell clearance and lupus-like autoimmune disease

定义凋亡细胞分解的分子调节因子及其在细胞清除和狼疮样自身免疫性疾病中的作用

• 批准号: nhmrc : GNT1140187
• 负责人: A/Pr Edwin Hawkins
• 金额: $ 77.38万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-molecular-regulators-autoimmune-disease/1348286
• 关键词: Defining; molecular; regulators; apoptotic; cell

In humans, billions of cells will die daily as part of normal turnover in various organs. It is vital that dying cells are rapidly removed as their accumulation has been linked to autoimmunity and inflammation. To aid efficient removal of dead cells, dying cells can disassemble into smaller fragments for neighbouring cells to engulf. We aim to understand the machinery that controls how dying cells can disassemble into smaller pieces and their function in cell clearance and autoimmunity.

在人类中，每天都会有数十亿细胞死亡，这是各种器官正常循环的一部分。死亡细胞的迅速清除是至关重要的，因为它们的积累与自身免疫和炎症有关。为了帮助有效地清除死细胞，垂死的细胞可以分解成更小的碎片，以供邻近的细胞吞噬。我们的目标是了解控制死亡细胞如何分解成小块的机制，以及它们在细胞清除和自身免疫中的作用。