Application of new chemistry approaches for antimalarial drug discovery

新化学方法在抗疟药物发现中的应用

• 批准号: nhmrc : 1038967
• 负责人: Dr Gillian Fisher
• 金额: $ 4.95万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/application-new-chemistry-drug-discovery/111235
• 关键词: Application; new; chemistry; approaches; antimalarial

Malaria kills approximately one million people annually. Currently there no vaccine and many of the available drugs are becoming less effective due the resistance of this highly adaptable parasite. My aim is to develop new chemical classes of drugs that inhibit different targets in the malaria parasite to the currently available drugs. In addition to this I aim to improve the present systems for assessing antimalarial drug effects using new chemical approaches and live parasite assays.

疟疾每年造成大约100万人死亡。目前没有疫苗，许多可用的药物由于这种高度适应性寄生虫的抗性而变得不那么有效。我的目标是开发新的化学类药物，抑制疟疾寄生虫的不同目标，以目前可用的药物。除此之外，我的目标是改善目前的系统，使用新的化学方法和活寄生虫检测评估抗疟药物的效果。