Assembly and egress of herpes simplex virus

单纯疱疹病毒的组装和排出

• 批准号: nhmrc : 457315
• 负责人: Dr Russell Diefenbach
• 金额: $ 19.22万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assembly-egress-herpes-simplex-virus/77460
• 关键词: Assembly; egress; herpes; simplex; virus

The occcurence of herpes simplex virus (HSV) in the general population is very high (up to 60%). In Central Africa, co-infection of HSV and HIV may increase HIV transmission in more than 40% of cases. HSV enters the human body via the skin before entering the termini of nerve cell processes. It is transported along these processes to the body of the nerve cell. HSV lies dormant within these nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported back down the nerve cell processes to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this project is to determine how HSV is assembled within cells at the molecular level. This will lead to identification of crucial molecular interactions required for viral assembly. Such information on viral assembly will allow development of inhibitors of this process which may be candidates for use as antivirals for control of recurrent herpes simplex. These antiviral agents will be able to target key viral molecular interactions in essentially all types of cells in the body and act against other herpesviruses in general.

单纯疱疹病毒（HSV）在普通人群中的发病率非常高（高达60%）。在中非，合并感染单纯疱疹病毒和艾滋病毒可能会增加40%以上病例的艾滋病毒传播。单纯疱疹病毒在进入神经细胞突末梢之前先通过皮肤进入人体。它沿着这些过程被运送到神经细胞的体内。HSV在大多数人的脊髓附近的这些神经细胞体中处于休眠状态。病毒间歇性地重新激活，并被运送回神经细胞过程到皮肤，在那里它引起水泡-溃疡或无症状地脱落。这个项目的目的是在分子水平上确定HSV是如何在细胞内组装的。这将导致鉴定病毒组装所需的关键分子相互作用。这些关于病毒组装的信息将有助于开发这一过程的抑制剂，这些抑制剂可能是用于控制复发性单纯疱疹的抗病毒药物的候选者。这些抗病毒药物将能够针对体内所有类型细胞中的关键病毒分子相互作用，并对其他疱疹病毒起作用。