Biological probes for understanding mammalian cellular transport mechanisms

细胞成分通过分子马达在细胞内移动。这一基本的运输机制依赖于轨道网络。阻止这种细胞传输可能会导致许多哺乳动物疾病，特别是在神经细胞内。这个项目将增加我们对细胞运输机制的了解，特别是分子马达如何接合他们的货物。这是开发针对这一转运机制的药物的重要基础。

Cellular components are moved around within cells by molecular motors. This fundamental transport mechanism depends on a network of tracks. Blocks in this cellular transport can result in a number of mammalian diseases, particularly within nerve cells. This project will increase our understanding of the mechanisms of cellular transport and, in particular, how molecular motors engage their cargo. This is essential groundwork for the development of drugs that target this transport mechanism.