Assembly and transport of herpes simplex virus within neurones

单纯疱疹病毒在神经元内的组装和运输

• 批准号: nhmrc : 253617
• 负责人: Dr Russell Diefenbach
• 金额: $ 31.71万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assembly-transport-herpes-virus-neurones/80972
• 关键词: Assembly; transport; herpes; simplex; virus

Herpes simplex virus (HSV) enters the human body via the skin before entering the termini of nerve cell processes. It is transported along these processes to the body of the nerve cell. HSV lies dormant within these nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported back down the nerve cell processes to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how HSV is transported and assemblied within nerve cells at the molecular level. Recent discoveries have shown how virus transport in nerve cells is dependent on interactions between specific viral proteins and cellular motor proteins. Such information on viral transport and assembly mechanisms will allow development of inhibitors of these processes which may be candidates for use as antivirals for control of recurrent herpes simplex. In addition, this information will allow the virus to be exploited for use in gene therapy to introduce DNA into human nerve cells to correct genetic abnormalities.

单纯疱疹病毒（HSV）在进入神经细胞突起末端之前通过皮肤进入人体。它被运输沿着这些过程到神经细胞的身体。HSV潜伏在大多数人脊髓附近的神经细胞体内。病毒间歇性地重新激活，并沿着神经细胞的过程转移到皮肤上，在那里它会引起水泡-溃疡，或者在没有症状的情况下脱落。这项资助的目的是确定HSV如何在分子水平上在神经细胞内运输和繁殖。最近的发现表明，病毒在神经细胞中的转运依赖于特定病毒蛋白和细胞运动蛋白之间的相互作用。关于病毒转运和组装机制的这些信息将允许开发这些过程的抑制剂，其可能是用作控制复发性单纯疱疹的抗病毒药物的候选物。此外，这些信息将使病毒能够用于基因治疗，将DNA引入人类神经细胞以纠正遗传异常。