Assessing acellular pertussis vaccine effectiveness: integrating transmission models, genetics and cohort data to inform policy

评估无细胞百日咳疫苗的有效性：整合传播模型、遗传学和队列数据为政策提供信息

• 批准号: nhmrc : 1128215
• 负责人: A/Pr James Wood
• 金额: $ 29.31万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assessing-acellular-pertussis-inform-policy/948160
• 关键词: Assessing; acellular; pertussis; vaccine; effectiveness

Between 2009-12 a very large epidemic of whooping cough occurred in Australia. More surprisingly during the course of the epidemic the bacteria that cause whooping cough showed genetic changes that seemed to avoid protection provided by the current vaccine against whooping cough in Australia. This grant seeks to use mathematical models of whooping cough transmission to explain how this occurred and to establish whether alternative vaccination strategies might improve the control of this disease.

2009年至2012年期间，澳大利亚发生了一场非常大规模的百日咳疫情。更令人惊讶的是，在疫情期间，引起百日咳的细菌表现出遗传变化，似乎避免了澳大利亚现有百日咳疫苗提供的保护。这项资助旨在使用百日咳传播的数学模型来解释这种情况是如何发生的，并确定替代疫苗接种策略是否可能改善对这种疾病的控制。