A Cluster Randomised Controlled Trial of Selective Decontamination of the Digestive Tract in Critically Ill Patients

重症患者消化道选择性净化的整群随机对照试验

• 批准号: nhmrc : 1084244
• 负责人: A/Pr Ian Seppelt
• 金额: $ 274.28万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cluster-randomised-controlled-ill-patients/518988
• 关键词: Cluster; Randomised; Controlled; Trial; Selective

Sepsis is the most common cause of death in intensive care patients. Selective Decontamination of the Digestive Tract (SDD) is a treatment to reduce the risk of infection and improve survival for these patients. Many trials suggest SDD works but there has not been widespread uptake due to concerns that SDD will increase antibiotic resistance.rates. This trial will provide a definitive answer. If SDD reduces mortality without increasing antibiotic resistance, the study will have a global impact.

脓毒症是重症监护患者最常见的死亡原因。选择性消化道去污（SDD）是一种降低感染风险并提高这些患者生存率的治疗方法。许多试验表明SDD工作，但由于担心SDD会增加抗生素耐药性，因此尚未广泛采用。这次审判将提供一个明确的答案。如果SDD在不增加抗生素耐药性的情况下降低死亡率，该研究将产生全球影响。