Antibiotic resistance and the ecological effects of selective decontamination of the digestive tract in Intensive Care Units

重症监护室抗生素耐药性和消化道选择性净化的生态效应

• 批准号: nhmrc : 1127292
• 负责人: A/Pr Ian Seppelt
• 金额: $ 61.66万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antibiotic-resistance-ecological-care-units/947983
• 关键词: Antibiotic; resistance; ecological; effects; selective

We will study patients within a large trial of gut decontamination, in which antibiotics are given in advance to reduce the risk of infection. Specifically, we will determine whether there is any increased antibiotic resistance and even biodiversity loss, as some fear. This is a one-off chance to provide essential data that can help us design better national policies for antibiotic resistance control and a true personalised medicine approach to resistance and infection in ICU.

我们将在一项大型肠道去污试验中对患者进行研究，在该试验中提前给予抗生素以降低感染风险。具体来说，我们将确定是否有任何增加的抗生素耐药性，甚至生物多样性的损失，因为有些人担心。这是一个提供必要数据的一次性机会，可以帮助我们设计更好的抗生素耐药性控制国家政策，以及针对ICU耐药性和感染的真正个性化医学方法。