The microenvironmental niche in cancer progression

癌症进展中的微环​​境生态位

• 批准号: nhmrc : 1025874
• 负责人: A/Pr Pritinder Kaur
• 金额: $ 37.52万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microenvironmental-niche-cancer-progression/110455
• 关键词: microenvironmental; niche; cancer; progression

It is well accepted that the cells in the local environment of cancers can help to promote the growth and spread of tumour cells. We have shown that a cell type known as the pericyte previously thought to be involved in controlling tumour expansion by affecting new blood vessel formation, may directly influence tumour growth, a notion that will be tested in human skin and ovarian cancer models. We will also test if pericyte markers can predict those cancer patients at greater risk of relapse.

人们普遍认为，癌症局部环境中的细胞有助于促进肿瘤细胞的生长和扩散。我们已经证明，一种称为周细胞的细胞类型以前被认为通过影响新血管形成来控制肿瘤扩张，可能会直接影响肿瘤生长，这一概念将在人类皮肤和卵巢癌模型中进行测试。我们还将测试周细胞标记是否可以预测那些复发风险较高的癌症患者。