Investigating human keratinocyte stem cells and their microenvironmental niche

皮肤上皮外保护层中的干细胞(角质形成细胞干细胞)具有天生的高再生组织能力。然而，这种组织再生能力可以通过与微环境元素，即结缔组织细胞和蛋白质的相互作用来增强。这项研究旨在研究特定的角质形成细胞-微环境相互作用，最终将用于改进目前为烧伤患者生成皮肤组织的方法。

The stem cells in the outer protective layers of the epithelium of the skin (keratinocyte stem cells), possess an intrinsically high capability to regenerate tissue. However, this tissue regenerative ability can be enhanced by interactions with microenvironmental elements i.e. connective tissue cells and proteins. This study seeks to investigate specific keratinocyte-microenvironment interactions which will ultimately be used to improve current methods for generating skin tissue for burns patients.