Investigating human keratinocyte stem cells and their microenvironmental niche

研究人类角质形成细胞干细胞及其微环境生态位

• 批准号: nhmrc : 1043453
• 负责人: A/Pr Pritinder Kaur
• 金额: $ 38.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-human-keratinocyte-microenvironmental-niche/111578
• 关键词: Investigating; human; keratinocyte; stem; cells

The stem cells in the outer protective layers of the epithelium of the skin (keratinocyte stem cells), possess an intrinsically high capability to regenerate tissue. However, this tissue regenerative ability can be enhanced by interactions with microenvironmental elements i.e. connective tissue cells and proteins. This study seeks to investigate specific keratinocyte-microenvironment interactions which will ultimately be used to improve current methods for generating skin tissue for burns patients.

皮肤上皮外保护层的干细胞（角质细胞干细胞）具有本质上高的组织再生能力。然而，这种组织再生能力可以通过与微环境因素（即结缔组织细胞和蛋白质）的相互作用而增强。本研究旨在研究特定的角化细胞-微环境相互作用，最终将用于改进目前烧伤患者皮肤组织生成的方法。