Patched gene family control of epidermal development and cancer

表皮发育和癌症的修补基因家族控制

• 批准号: nhmrc : 519748
• 负责人: A/Pr Pritinder Kaur
• 金额: $ 34.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/patched-gene-family-development-cancer/78373
• 关键词: Patched; gene; family; control; epidermal

The skin is the largest organ in the body and functions as a barrier against infection and dehydration. From a clinical perspective we need to know how to regenerate skin for better wound healing and the treatment of burns. We have identified a genetic pathway that regulates the stem cells of the skin and this research will show us the mechanism whereby the skin develops and regenerates, as well as the possible manipulations we can use to increase healing in the clinic.

皮肤是人体最大的器官，起着防止感染和脱水的屏障作用。从临床的角度来看，我们需要知道如何再生皮肤，以更好地愈合伤口和治疗烧伤。我们已经确定了一种调节皮肤干细胞的遗传途径，这项研究将向我们展示皮肤发育和再生的机制，以及我们可以用来增加临床愈合的可能操作。