The mutagenic influence of 5-methylcytosine and its relevance for cancer treatment

5-甲基胞嘧啶的致突变影响及其与癌症治疗的相关性

• 批准号: nhmrc : GNT1145912
• 负责人: A/Pr Marco Herold
• 金额: $ 84.45万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mutagenic-influence-5-cancer-treatment/1348727
• 关键词: mutagenic; influence; methylcytosine; its; relevance

Over time our cells accumulate damage to their DNA, which introduces mistakes in the genetic code. These mistakes can alter genes that regulate cell growth and survival and, in this way, they begin the process of turning a normal cell into a cancer. This research is investigating the cellular repair mechanisms that safeguard against DNA damage. Manipulating these repair mechanisms may offer a new way to treat cancer, by selectively inducing DNA damage within cancer cells.

随着时间的推移，我们的细胞对DNA的损害不断累积，从而在遗传密码中引入错误。这些错误可以改变调节细胞生长和存活的基因，通过这种方式，它们开始将正常细胞转变为癌症的过程。这项研究是研究细胞修复机制，以防止DNA损伤。通过选择性地诱导癌细胞内的DNA损伤，操纵这些修复机制可能会提供一种治疗癌症的新方法。