The role of the pro-survival Bcl-2 family member A1 in the development and sustained growth of lymphomas.

促生存 Bcl-2 家族成员 A1 在淋巴瘤发生和持续生长中的作用。

• 批准号: nhmrc : 1049720
• 负责人: A/Pr Marco Herold
• 金额: $ 41.91万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-pro-survival-growth-lymphomas/112107
• 关键词: role; pro; survival; Bcl; family

The death of cells, which is regulated by a complex interaction between cell survival and killer proteins, is an important mechanism to prevent cancer. In this proposal we aim to understand the function of one of the cell survival proteins in cancer development and maintenance. This will help to develop novel therapeutic drugs specifically targeting this cell survival protein, thereby eliminating specifically the cancer cells and minimizing collateral damage of healthy tissues.

细胞死亡是预防癌症的重要机制，受细胞存活和杀伤蛋白之间复杂的相互作用调控。在这个提议中，我们的目标是了解一个细胞存活蛋白在癌症发展和维持中的功能。这将有助于开发专门针对这种细胞存活蛋白的新型治疗药物，从而特异性地消除癌细胞并最大限度地减少对健康组织的附带损害。