Elucidating the cellular processes that are critical for p53 mediated tumour suppression

阐明对 p53 介导的肿瘤抑制至关重要的细胞过程

• 批准号: nhmrc : GNT1143105
• 负责人: A/Pr Marco Herold
• 金额: $ 101.61万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-cellular-processes-tumour-suppression/1348504
• 关键词: Elucidating; cellular; processes; critical; p53

p53 is a tumour suppressor gene that is mutated in ~50% of human cancers. Mutations in p53 cause development of cancer and render malignant cells resistant to chemotherapy. We have identified genes regulated by p53 that appear critical for its tumour suppressive function. In this project, we will use innovative novel genetic tools to discover the cellular and biochemical functions of these genes. The ultimate goal of our studies is to identify novel targets for anti-cancer therapy.

p53是一种肿瘤抑制基因，在约50%的人类癌症中发生突变。p53突变导致癌症的发展，并使恶性细胞对化疗产生耐药性。我们已经确定了由p53调控的基因，这些基因对p53的肿瘤抑制功能至关重要。在这个项目中，我们将使用创新的新型遗传工具来发现这些基因的细胞和生化功能。我们研究的最终目标是确定抗癌治疗的新靶点。