The ongoing evolution of class 1 integrons and the recruitment of new resistance and virulence genes into pathogens

1 类整合子的持续进化以及病原体中新的抗性和毒力基因的招募

• 批准号: nhmrc : 543402
• 负责人: A/Pr Andrew Holmes
• 金额: $ 35.13万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ongoing-evolution-class-genes-pathogens/97977
• 关键词: ongoing; evolution; class; integrons; recruitment

Bacteria are remarkably adaptive and evolve in ways that plants and animals do not. One of these ways is Lateral Gene Transfer (LGT), a process allowing one bacterial cell in a community to give genes that have been developed or acquired to other members of the community. This is a process that has led to the problem of multi drug resistance. This project aims to understand and thereby limit the movement of resistance genes from harmless bacteria into those that cause disease in humans.

细菌具有很强的适应性，其进化方式是植物和动物所不具备的。其中一种方法是横向基因转移(LGT)，这是一种允许社区中的一个细菌细胞将已经开发或获得的基因传递给社区其他成员的过程。这是一个导致多药耐药问题的过程。该项目旨在了解并从而限制抗药性基因从无害细菌进入那些会导致人类疾病的细菌。