The pathogenic role of a placenta-specific protease in early-onset preeclampsia

胎盘特异性蛋白酶在早发性先兆子痫中的致病作用

• 批准号: nhmrc : GNT1108365
• 负责人: Prof Guiying Nie
• 金额: $ 60.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathogenic-role-placenta-onset-preeclampsia/1346643
• 关键词: pathogenic; role; placenta; specific; protease

Preeclampsia (PE) is a life-threatening disorder of pregnancy. If left untreated, PE will lead to maternal as well as fetal death. Unfortunately, the only current effective “cure” for PE is to deliver the baby prematurely. The causes of PE are intrinsically related to the placenta, the organ that connects the fetus to the mother. This project will investigate a unique enzyme that is produced only by the placenta, its contribution to PE and its potential as a target for PE treatment.

先兆子痫（PE）是一种危及生命的妊娠期疾病。如果不及时治疗，PE将导致母体和胎儿死亡。不幸的是，目前唯一有效的“治疗”PE是早产。PE的原因与胎盘有内在的联系，胎盘是连接胎儿和母亲的器官。该项目将研究一种仅由胎盘产生的独特酶，其对PE的贡献及其作为PE治疗靶点的潜力。