The pathogenic role of a placenta-specific protease in early-onset preeclampsia

子痫前期(PE)是一种危及生命的妊娠疾病。如果不进行治疗，PE将导致产妇和胎儿死亡。不幸的是，目前唯一有效的PE治疗方法是早产。PE的原因本质上与胎盘有关，胎盘是连接胎儿和母亲的器官。这个项目将研究一种仅由胎盘产生的独特的酶，它对PE的贡献，以及它作为PE治疗靶点的潜力。

Preeclampsia (PE) is a life-threatening disorder of pregnancy. If left untreated, PE will lead to maternal as well as fetal death. Unfortunately, the only current effective “cure” for PE is to deliver the baby prematurely. The causes of PE are intrinsically related to the placenta, the organ that connects the fetus to the mother. This project will investigate a unique enzyme that is produced only by the placenta, its contribution to PE and its potential as a target for PE treatment.