The pharmacology of sulfotransferase 4A1

磺基转移酶4A1的药理学

• 批准号: nhmrc : 1099135
• 负责人: Dr Neville Butcher
• 金额: $ 39.56万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacology-sulfotransferase-4a1/662422
• 关键词: pharmacology; sulfotransferase; 4A1

SULT4A1 is not a sulfotransferase, but a sulfotransferase inhibitor. It forms high affinity heterodimers with other sulfotransferases via a conserved dimerisation site in its carboxyl terminus attenuating catalytic activity. Consequently, it is important for the metabolism of numerous important molecules including estrogens, thyroid hormones, neurotransmitters and many therapeutic agents.

SULT4A1不是磺基转移酶，而是磺基转移酶抑制剂。它通过其羧基末端的保守二聚化位点与其他磺基转移酶形成高亲和力异二聚体，从而减弱催化活性。因此，它对许多重要分子的代谢很重要，包括雌激素、甲状腺激素、神经递质和许多治疗剂。