Role of the drug metabolising enzyme arylamine N-acetyltransferase 1 in breast cancer

药物代谢酶芳胺 N-乙酰转移酶 1 在乳腺癌中的作用

• 批准号: nhmrc : 1024769
• 负责人: Dr Neville Butcher
• 金额: $ 40.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-drug-metabolising-breast-cancer/110372
• 关键词: Role; drug; metabolising; enzyme; arylamine

The current project will identify the molecular mechanism(s) that underpins the significant changes in phenotype seen in a range of human cancer cells. The expected outcomes will be to demonstrate that NAT1 is critical for the clearance of pABG in cancer cells. The results will be important in the context of understanding this family of intracellular enzymes and will change the current thinking on the function of the arylamine N-acetyltransferase in normal and cancer cells.

当前的项目将确定支撑一系列人类癌细胞表型显着变化的分子机制。预期结果将证明 NAT1 对于癌细胞中 pABG 的清除至关重要。这些结果对于理解这个细胞内酶家族非常重要，并将改变目前对正常细胞和癌细胞中芳胺 N-乙酰转移酶功能的看法。