The predictors of knee cartilage loss: A 5 year natural history study based on an existing cohort

膝关节软骨损失的预测因素：基于现有队列的 5 年自然史研究

• 批准号: nhmrc : 194439
• 负责人: Prof Andrew Forbes
• 金额: $ 5.09万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/predictors-knee-cartilage-existing-cohort/77523
• 关键词: predictors; knee; cartilage; loss; year

Osteoarthritis (OA) is the single biggest cause of disability in Western society. Despite this, relatively little is known about the factors that effect disease progression. This will be the first extended follow up study of cartilage volume in people with early OA. This study will build on our existing work where we have developed a cohort study of adults with early knee OA. These people were initially recruited in 1997-8. An extensive data base of potential risk factors for OA has been collected and both X-rays of the knee and MRI have been performed at baseline and 2 years. Extending the follow up from 2 to 5 years will allow not only more precise estimation of rates of cartilage loss and assessment of risk factors, but also enable assessment of the assumption of linearity of cartilage volume loss. It will also be possible to partition the observed variability in rates of loss into true between-subject variability and within subject residual variability. This partitioning will provide valuable information for the design of future studies in OA, similar to the establishment of statistical design principles for patterns of loss in bone mineral density.

骨关节炎(OA)是西方社会导致残疾的最大原因。尽管如此，人们对影响疾病进展的因素知之甚少。这将是第一次对早期骨性关节炎患者的软骨体积进行长期随访研究。这项研究将建立在我们现有工作的基础上，我们已经对患有早期膝骨性关节炎的成年人进行了一项队列研究。这些人最初是在1997-2008年招募的。我们收集了一个关于骨性关节炎潜在危险因素的广泛数据库，并在基线和2年进行了膝关节X光和核磁共振检查。将随访时间从2年延长到5年，不仅可以更准确地估计软骨损失率和评估危险因素，而且还可以评估软骨体积损失的线性假设。还可以将观察到的损失率变异性划分为受试者之间的真实变异性和受试者内部的残差变异性。这种划分将为未来骨关节炎研究的设计提供有价值的信息，类似于建立骨密度丢失模式的统计设计原则。