Role of musculoskeletal biomechanical factors in cartilage loss in those who undergo partial medial menisectomy.
肌肉骨骼生物力学因素在接受部分内侧半月板切除术的患者软骨损失中的作用。
基本信息
- 批准号:nhmrc : 334151
- 负责人:
- 金额:$ 43.64万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2005
- 资助国家:澳大利亚
- 起止时间:2005-01-01 至 2008-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The novel outcomes from our project are that we will identify whether musculoskeletal-biomechanical factors that can be modified are associated with adverse cartilage changes in a subgroup of individuals with an increased risk of developing knee OA, those who have undergone an APM. The findings of this research are timely and of major international significance as there is increasing attention being paid to preventing OA rather than merely treating the signs and symptoms. Our state-of-the-art measure of cartilage changes will allow us to detect those at risk much sooner than traditional measures using radiographs. The measures are also leading edge internationally. We chose these specific factors to investigate as there is evidence that they can be modified with appropriate interventions. For example, static joint alignment could be modified with foot orthoses [Crenshaw, 2000 #1016], muscle weakness can be addressed with strength programs and mechanical loading across the knee could be reduced via weight loss programs or techniques to alter gait patterns. Currently, formal supervised post-operative rehabilitation is not routinely prescribed following APM because it is considered a routine procedure. If our research identifies risk factors for increased cartilage loss then we will be able to develop appropriate intervention strategies for individuals following an APM. These interventions can then be formally tested as to their effectiveness in reducing adverse cartilage changes using randomised controlled trials. In particular, this could lead to changes in current post-operative clinical practice for this patient group. Ultimately, this could reduce the risk of OA in the future and the resultant personal and societal costs of this condition.
我们项目的新成果是,我们将确定可以修改的肌肉骨骼生物力学因素是否与膝骨性关节炎风险增加的一组人(那些经历了APM的人)的软骨不良变化有关。这项研究的结果是及时的,具有重大的国际意义,因为人们越来越重视预防骨性关节炎,而不仅仅是治疗症状和体征。我们最先进的软骨变化测量方法将使我们能够比使用X光照片的传统测量方法更快地发现那些处于危险中的人。这些措施在国际上也处于领先地位。我们选择这些特定的因素进行调查,因为有证据表明,通过适当的干预可以改变这些因素。例如,静态关节对齐可以通过足部矫形器来改变[Crenshaw,2000#1016],肌肉无力可以通过力量计划来解决,膝关节上的机械负荷可以通过减肥计划或改变步态模式的技术来减少。目前,在APM后,正式的有监督的术后康复并不是常规的处方,因为这被认为是一种常规程序。如果我们的研究确定了软骨丢失增加的危险因素,那么我们将能够为急性早幼粒细胞白血病患者制定适当的干预策略。然后,可以使用随机对照试验来正式测试这些干预措施在减少软骨不良变化方面的有效性。特别是,这可能会导致这一患者群体目前的术后临床实践发生变化。最终,这可以降低未来发生骨性关节炎的风险,以及由此产生的个人和社会成本。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Prof Andrew Forbes其他文献
Prof Andrew Forbes的其他文献
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{{ truncateString('Prof Andrew Forbes', 18)}}的其他基金
Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery: The RELIEF Trial
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- 批准号:
nhmrc : 1043755 - 财政年份:2013
- 资助金额:
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Effect of lifestyle factors on knee cartilage volume and rate of cartilage loss in a normal population
生活方式因素对正常人群膝关节软骨体积和软骨损失率的影响
- 批准号:
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- 资助金额:
$ 43.64万 - 项目类别:
NHMRC Project Grants
Efficacy and cost-effectiveness of physiotherapy for chronic rotator cuff pathology
物理治疗慢性肩袖病理的疗效和成本效益
- 批准号:
nhmrc : 299840 - 财政年份:2004
- 资助金额:
$ 43.64万 - 项目类别:
NHMRC Project Grants
The Alfred/Monash Centre for Therapeutics and Clinical Research
阿尔弗雷德/莫纳什治疗和临床研究中心
- 批准号:
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- 资助金额:
$ 43.64万 - 项目类别:
Centre for Research Excellence
Efficacy of physiotherapy after hydrodilatation for the painful stiff shoulder: a randomised placebo-controlled trial
水扩张后物理治疗对疼痛性僵硬肩部的疗效:一项随机安慰剂对照试验
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$ 43.64万 - 项目类别:
NHMRC Project Grants
The predictors of knee cartilage loss: A 5 year natural history study based on an existing cohort
膝关节软骨损失的预测因素:基于现有队列的 5 年自然史研究
- 批准号:
nhmrc : 194439 - 财政年份:2002
- 资助金额:
$ 43.64万 - 项目类别:
NHMRC Project Grants
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