The effects of damage and repair of fungal DNA on animal and plant diseases

真菌DNA损伤与修复对动植物病害的影响

• 批准号: FT130100146
• 负责人: A/Prof Alexander Idnurm
• 金额: $ 51.32万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-06-23 至 2018-06-22
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100146
• 关键词: effects; damage; repair; fungal; DNA

DNA damage and its repair are implicated in enhancing the ability of fungi to cause disease. These processes enable genomic changes that generate fungal strains better adapted to host colonisation. This project will identify factors that influence mutation, virulence and host adaptation in two model fungi that cause devastating diseases - a human pathogen, Cryptococcus neoformans, and a plant pathogen, Leptosphaeria maculans. Since increases in global temperatures are expected to lead to emerging fungal diseases, understanding effects of damage and repair of fungal DNA on animal and plant diseases is key to designing disease control approaches.

DNA损伤及其修复与增强真菌致病能力有关。这些过程使基因组发生变化，产生更好地适应宿主定殖的真菌菌株。该项目将确定影响突变，毒力和宿主适应的因素，在两个模式真菌，导致毁灭性的疾病-人类病原体，新型隐球菌，和植物病原体，Leptosphaeria maculans。由于全球气温的升高预计将导致新出现的真菌疾病，因此了解真菌DNA的损伤和修复对动植物疾病的影响是设计疾病控制方法的关键。