Aurora kinase: molecular, cellular and functional studies deciphering its role in stroke injury

极光激酶：分子、细胞和功能研究破译其在中风损伤中的作用

• 批准号: nhmrc : 1023646
• 负责人: A/Pr Peter Crack
• 金额: $ 38.74万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/aurora-kinase-molecular-stroke-injury/110289
• 关键词: Aurora; kinase; molecular; cellular; functional

In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating an enzyme called aurora kinase A (AURKA). We aim at unravelling (i) how AURKA is activated by oxygen deprivation, (ii) where the activated AURKA is localised in cells, and (iii) how the activated AURKA induces nerve cell death.The study will benefit development of therapeutic strategies to protect against brain damage in stroke since this is novel and different target for drug targeting.

在中风患者中，缺氧通过激活一种称为极光激酶A（AURKA）的酶间接诱导大量神经细胞死亡。我们的目标是解开（i）如何激活缺氧AURKA，（ii）激活的AURKA在细胞中的位置，以及（iii）激活的AURKA如何诱导神经细胞死亡。这项研究将有利于开发治疗策略，以防止脑损伤中风，因为这是新的和不同的药物靶向目标。