APLP2: a neuroprotective receptor for acute brain injury

APLP2：急性脑损伤的神经保护受体

• 批准号: nhmrc : 1120583
• 负责人: A/Pr Peter Crack
• 金额: $ 44.3万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/aplp2-neuroprotective-receptor-brain-injury/946576
• 关键词: APLP2; neuroprotective; receptor; acute; brain

Traumatic brain injury (TBI) is the major cause of deaths in Australians under 45 years of age. We have shown that the amyloid precursor protein (APP) is protective in models of TBI. To understand how APP is neuroprotective we have isolated APP binding proteins and identified the amyloid precursor-like protein 2 (APLP2) molecule as a strong candidate for the APP-neuroprotective receptor. This grant will investigate the interaction between APP and APLP2 as a novel neuroprotective pathway in TBI.

创伤性脑损伤（TBI）是45岁以下澳大利亚人死亡的主要原因。我们已经证明淀粉样前体蛋白（APP）在TBI模型中具有保护作用。为了了解APP是如何神经保护的，我们分离了APP结合蛋白，并确定了淀粉样蛋白受体样蛋白2（APLP2）分子作为APP神经保护受体的强有力的候选者。该基金将研究APP和APLP2之间的相互作用，作为TBI中一种新的神经保护途径。