Understanding neuroinflammation in Alzheimer's Disease

了解阿尔茨海默病的神经炎症

• 批准号: nhmrc : 1142989
• 负责人: A/Pr Peter Crack
• 金额: $ 70.54万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-neuroinflammation-alzheimers-disease/1319842
• 关键词: Understanding; neuroinflammation; Alzheimer; Disease

This project opens a new line of enquiry into the cellular signalling mechanisms involved in the progression of AD and establishes whether targeting the involvement of type-1 IFN signalling influences the evolution of AD. New and novel approaches are clearly required to treat AD. Importantly, we believe that neuroinflammation is common to all causes of dementia and targeting the neuroinflammatory pathways has much wider implications than targeting the primary causative pathway.

该项目开启了一条新的研究AD进展过程中涉及的细胞信号机制的途径，并建立了针对1型干扰素信号参与是否影响AD演变的靶向。治疗阿尔茨海默病显然需要新的和新颖的方法。重要的是，我们认为神经炎症在所有痴呆的病因中都是常见的，针对神经炎症途径比针对主要致病途径具有更广泛的意义。