Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells
Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells
批准号:
nhmrc : 570995
负责人:
A/Pr Beric Henderson
金额:
$34.12万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2012-12-31
中文摘要
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英文摘要
Inherited gene mutations that cause colon cancer kill 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by age 75. Activation of the beta-catenin protein is a critical switch in the path to colon cancer. We discovered that beta-catenin, and another protein it interacts with called IQGAP1, move between different cellular compartments. We plan to study this process in more detail, as it relates to how beta-catenin works and to understanding its role in cancer.
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Characterising the beta-catenin nuclear targeting pathway in cancer
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批准号:nhmrc : 1046767
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负责人:A/Pr Beric Henderson
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依托单位:
Targeting of the APC tumour suppressor to mitochondria: Implications for APC regulation and cellular function
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批准号:nhmrc : 512372
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资助金额:$26.01万
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财政年份:2008
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负责人:A/Pr Beric Henderson
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 511911
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项目类别:NHMRC Research Fellowships
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资助金额:$49.22万
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财政年份:2008
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负责人:A/Pr Beric Henderson
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依托单位:
"Regulation of beta-catenin localisation and its role in tumour cell migration"
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批准号:nhmrc : 402531
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项目类别:NHMRC Project Grants
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资助金额:$18.12万
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财政年份:2006
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负责人:A/Pr Beric Henderson
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依托单位:
Regulation of BRCA1 and APC tumour suppressor functions by nuclear export
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批准号:nhmrc : 253727
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依托单位:
Breast and Colon Cancer
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资助金额:$34.47万
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财政年份:2003
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负责人:A/Pr Beric Henderson
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依托单位:
Regulation of the tumour suppressors APC and BRCA1 by nuclear export
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批准号:nhmrc : 107350
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资助金额:$35.4万
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财政年份:2000
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负责人:A/Pr Beric Henderson
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依托单位:
国内基金
海外基金
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批准号:31970730
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依托单位:
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批准年份:2016
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依托单位: