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Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells

Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells
迁移细胞中 β-连环蛋白和 IQGAP1 在细胞核和质膜之间的调节穿梭
批准号:
nhmrc : 570995
负责人:
A/Pr Beric Henderson
金额:
$34.12万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2012-12-31

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中文摘要
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英文摘要
Inherited gene mutations that cause colon cancer kill 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by age 75. Activation of the beta-catenin protein is a critical switch in the path to colon cancer. We discovered that beta-catenin, and another protein it interacts with called IQGAP1, move between different cellular compartments. We plan to study this process in more detail, as it relates to how beta-catenin works and to understanding its role in cancer.
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Characterising the beta-catenin nuclear targeting pathway in cancer
  • 批准号:
    nhmrc : 1046767
  • 项目类别:
    Project Grants
  • 资助金额:
    $32.35万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Beric Henderson
  • 依托单位:
Targeting of the APC tumour suppressor to mitochondria: Implications for APC regulation and cellular function
  • 批准号:
    nhmrc : 512372
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $26.01万
  • 财政年份:
    2008
  • 负责人:
    A/Pr Beric Henderson
  • 依托单位:
Uncoupled Research Fellowship
  • 批准号:
    nhmrc : 511911
  • 项目类别:
    NHMRC Research Fellowships
  • 资助金额:
    $49.22万
  • 财政年份:
    2008
  • 负责人:
    A/Pr Beric Henderson
  • 依托单位:
"Regulation of beta-catenin localisation and its role in tumour cell migration"
  • 批准号:
    nhmrc : 402531
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $18.12万
  • 财政年份:
    2006
  • 负责人:
    A/Pr Beric Henderson
  • 依托单位:
国内基金
海外基金
核孔蛋白NUP62调控开花时间的分子机制
  • 批准号:
    31970730
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2019
  • 负责人:
    胡红红
  • 依托单位:
NR2B-CaMKⅡα-HDAC4 shuttling 信号通路在瑞芬太尼痛觉过敏中的调控机制
  • 批准号:
    81600962
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    17.0万元
  • 批准年份:
    2016
  • 负责人:
    王春艳
  • 依托单位: