Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells

迁移细胞中 β-连环蛋白和 IQGAP1 在细胞核和质膜之间的调节穿梭

• 批准号: nhmrc : 570995
• 负责人: A/Pr Beric Henderson
• 金额: $ 34.12万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulated-shuttling-beta-migrating-cells/95043
• 关键词: Regulated; shuttling; beta; catenin; IQGAP1

Inherited gene mutations that cause colon cancer kill 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by age 75. Activation of the beta-catenin protein is a critical switch in the path to colon cancer. We discovered that beta-catenin, and another protein it interacts with called IQGAP1, move between different cellular compartments. We plan to study this process in more detail, as it relates to how beta-catenin works and to understanding its role in cancer.

导致结肠癌的遗传基因突变每年导致4700名澳大利亚人死亡。大约每21名澳大利亚人中就有一人在75岁之前患上结直肠癌。β-连环蛋白的激活是结肠癌发生过程中的一个关键开关。我们发现，β-连环蛋白，以及与之相互作用的另一种名为IQGAP1的蛋白质，可以在不同的细胞间移动。我们计划更详细地研究这一过程，因为它与β-连环蛋白的工作原理有关，并与了解其在癌症中的作用有关。