Targeting of the APC tumour suppressor to mitochondria: Implications for APC regulation and cellular function

APC 肿瘤抑制因子靶向线粒体：对 APC 调节和细胞功能的影响

• 批准号: nhmrc : 512372
• 负责人: A/Pr Beric Henderson
• 金额: $ 26.01万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-apc-tumour-cellular-function/82586
• 关键词: Targeting; APC; tumour; suppressor; mitochondria

Inherited mutations in the APC gene cause colon cancer, and kills 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by the age of 75. APC mutations change cells in different ways, triggering the cancer process. We have discovered a new pathway, involving altered movement of APC to mitochondria in tumour cells. This study will investigate how this cancerous change may help our understanding of colon cancer progression.

APC基因的遗传突变导致结肠癌，每年导致4,700名澳大利亚人死亡。大约每21名澳大利亚人中就有1人在75岁时患上结直肠癌。APC突变以不同的方式改变细胞，触发癌症过程。我们已经发现了一种新的途径，涉及改变APC向肿瘤细胞线粒体的运动。这项研究将探讨这种癌变如何帮助我们了解结肠癌的进展。