Benefits and safety of IRon supplementation with MAlaria chemoprevention to children in Malawi (IRMA) - A randomised controlled trial

马拉维儿童补充 IRon 和疟疾化学预防的益处和安全性 (IRMA) - 一项随机对照试验

• 批准号: nhmrc : 1141185
• 负责人: Dr Jena Hamadani
• 金额: $ 207.19万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/benefits-safety-iron-controlled-trial/1319392
• 关键词: Benefits; safety; IRon; supplementation; MAlaria

Anaemia and malaria frequently coexist in low income settings e.g. sub-Saharan Africa and Asia. Iron interventions aim to reduce anaemia but exacerbate malaria. We aim to test whether iron is made safe by coadministering malaria prevention, and whether these interventions improve child health outcomes especially cognitive development, while ensuring malaria resistance does not emerge.

在撒哈拉以南非洲和亚洲等低收入环境中，贫血和疟疾经常并存。铁干预措施旨在减少贫血，但加剧疟疾。我们的目标是测试铁是否通过共同管理疟疾预防而变得安全，以及这些干预措施是否改善儿童健康结果，特别是认知发展，同时确保疟疾耐药性不会出现。