Bile Acid and Neurosteroid Signaling to the Nervous System

胆汁酸和神经类固醇向神经系统发出信号

• 批准号: nhmrc : 1031886
• 负责人: Dr Daniel Poole
• 金额: $ 39.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bile-acid-neurosteroid-signaling-nervous/110828
• 关键词: Bile; Acid; Neurosteroid; Signaling; Nervous

Defects in the secretion of bile into the intestine cause digestive diseases, and abnormal circulating levels of bile acids induce profound itch and abnormal pain sensation. This project examines whether a cell-surface receptor (TGR5) produced by intestinal and sensory neurons mediates actions of bile acids on intestinal functions, itch and pain. The project will define mechanisms of digestive and sensory disorders and identify new therapies for constipation, diarrhoea, itch and pain.

胆汁分泌到肠道中的缺陷会引起消化系统疾病，胆汁酸的异常循环水平会引起严重的瘙痒和异常的疼痛感。本项目研究是否由肠道和感觉神经元产生的细胞表面受体（TGR 5）介导胆汁酸对肠道功能，瘙痒和疼痛的作用。该项目将确定消化和感觉障碍的机制，并确定便秘、腹泻、瘙痒和疼痛的新疗法。