Spatial and temporal dimensions of mu-opioid receptor signalling: implications for the development of tolerance

mu-阿片受体信号传导的空间和时间维度：对耐受性发展的影响

• 批准号: nhmrc : GNT1121029
• 负责人: Dr Daniel Poole
• 金额: $ 79.93万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/spatial-temporal-dimensions-development-tolerance/1347179
• 关键词: Spatial; temporal; dimensions; mu; opioid

The use of morphine as an analgesic is still limited by undesirable side effects such as tolerance. Despite decades of research, the mechanisms behind the development of tolerance are poorly understood. The μ opioid receptor is a protein expressed at the surface of the cells that is the target of morphine. This project will investigate the signalling events triggered by opioids with unprecedented resolution and will aim to elucidate why morphine elicits more tolerance than other opioid drugs.

吗啡作为止痛剂的使用仍然受到不希望的副作用如耐受性的限制。尽管进行了数十年的研究，但人们对耐受性发展背后的机制知之甚少。μ阿片受体是一种在细胞表面表达的蛋白质，是吗啡的靶点。该项目将以前所未有的分辨率调查阿片类药物引发的信号事件，并旨在阐明为什么吗啡比其他阿片类药物更具耐受性。