Telemetry monitoring equipment to understand behavioral components of nutrition and metabolism

我的要求是购买新的数据科学国际(DSI)遥测生理监测设备适用于小动物(啮齿动物)。到目前为止，由于技术和成本的限制，我们艾伯塔大学的营养小组无法获得这种设备。该设备将实现目前在我们的研究环境中任何地方都无法获得的独特和创新的数据采集组合。遥测设备是最先进的技术，可以在动物的正常行为环境中连续远程监测血压、温度、心脏电活动和身体活动。我们的研究项目目前将营养、肥胖和厌食症整合到一个单一的饮食、体重和体力活动的神经化学模型中，这显然具有全球性影响，包括心血管疾病(CVD)和其他体重相关疾病的风险。我们知道，在这些疾病中，体力活动或锻炼在能量消耗和能量平衡方面发挥着重要作用。通过亚利桑那大学的跨学科合作，我们开发了肥胖和运动性厌食症的小动物模型。饮食和营养补充对慢性病期间影响的基本生理参数有实质性影响，包括心血管参数，如心功能、呼吸和血压。此外，在限食期间车轮转动破坏能量平衡需要在生理水平上有更直接的证据，而新的DSI设备的影响将使对这一范式的创新见解成为可能。因此，从这台新设备收集的数据将在营养、新陈代谢、行为和社会学等广泛的跨学科领域进行解释，这将使HQP培训环境更加全面和综合。这将是亚利桑那州大学营养相关项目第一次获得这种类型的设备，特别是它将创新我们研究项目的跨学科行为-营养方法。

My request is to purchase new Data Sciences International (DSI) telemetry physiologic monitoring equipment applicable for small animals (rodents). To date this equipment has been inaccessible to our Nutrition group at the University of Alberta due to limitations of technology and cost. The equipment will enable a unique and innovative composite of data acquisition that at present are not available anywhere within our research environment. The telemetric equipment is state-of the-art technology that can monitor blood pressure, temperature, heart electrical activity and physical activity, all remotely, on a continuous basis in the normal behavioral environment of the animal. Our research programs currently integrate nutrition, obesity and anorexia within a single neurochemical model of eating, body weight and physical activity, which clearly has global implications including risks for cardiovascular disease (CVD) and other weight-related disorders. We know that physical activity or exercise plays an important role in energy expenditure and energy balance in these disorders. Through cross-discipline collaborations at the U of A, we have developed small animal models for both obesity and activity anorexia. Dietary and nutritional supplementation has a substantive impact on basic physiological parameters affected during chronic disease including CVD parameters such as cardiac function (ECG), respiration and blood pressure. Moreover, the disruption of energy balance by wheel running during food-restriction requires more direct evidence at the physiological level and the impact of the new DSI equipment will enable innovative insights into this paradigm. Consequently, data collected from this new equipment will be interpreted across broad trans-disciplinary fields of nutrition, metabolism, behavioral and sociological contexts, which will allow a more comprehensive integrated HQP training environment. It will be the first time that nutritional-related programs at the U of A will have access to this type of equipment, in particular it will innovate the trans-disciplinary behavioral-nutritional approach to our research program.