Biological actions of estradiol in men

雌二醇对男性的生物学作用

• 批准号: nhmrc : 1099173
• 负责人: Prof David Handelsman
• 金额: $ 42.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biological-actions-estradiol-men/662430
• 关键词: Biological; actions; estradiol; men

In men, oestrogen may be important for strong bones and maintaining a healthy weight. Men with prostate cancer are given medical castration treatment to decrease testosterone, because testosterone is required for prostate cancer growth. Because oestrogen is derived from testosterone, they also have very low oestrogen levels. We want to conduct a trial in these men to find out whether giving back oestrogen will prevent bone loss and weight gain, among other health benefits.

对于男性来说，雌激素可能对强健骨骼和保持健康体重很重要。患有前列腺癌的男性会接受药物阉割治疗，以降低睾酮，因为前列腺癌的生长需要睾酮。因为雌激素来源于睾丸素，所以它们的雌激素水平也很低。我们想在这些男性身上进行一项试验，以找出补充雌激素是否能防止骨质流失和体重增加，以及其他健康益处。