The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of Age
早产儿微生物组:2 岁和 4 岁时的生物学、行为和健康结果
基本信息
- 批准号:8857645
- 负责人:
- 金额:$ 56.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-05-13 至 2020-02-29
- 项目状态:已结题
- 来源:
- 关键词:4 year oldAdultAffectAgeAntibioticsApoptoticBacteriaBiologicalBirthCesarean sectionChildChildhoodCollectionColony-forming unitsCommunitiesConsumptionDataDependencyDevelopmentDietEnrollmentEnteralEnvironmentEnvironmental Risk FactorEpithelial CellsEquilibriumEventExposure toFecesFoodGastrointestinal MotilityGenesGestational AgeGrantGrowthGrowth FactorGrowth and Development functionHealthHealth StatusHome environmentHospitalsHuman MilkHypersensitivityImmuneImmunobiologyIndwelling CatheterInfantInfectionInflammationInflammatoryIntakeIntestinesLaboratoriesLeadLength of StayLeukocyte L1 Antigen ComplexLifeLymphoid TissueMeasuresMicrobeMilkNeonatal Intensive Care UnitsNewborn InfantOralOutcomeOxygenPhysiologicalPremature InfantProceduresProspective StudiesReceptor SignalingResistanceRiskRoleSamplingScienceSecretory Immunoglobulin AShapesSmokingSourceSteroidsStimulusStressStructureTestingTimeToll-like receptorsVaginaVery Low Birth Weight InfantWeaningWeight Gainatopybehavioral healthburden of illnesschemokinecohortcommensal microbescytokinedeep sequencingexperiencefeedinggut microbiotaimmune activationinfancymicrobialmicrobial communitymicrobiomeneonatenovelpathogenpostnatalprenatalprospectivepublic health relevance
项目摘要
DESCRIPTION (provided by applicant): This project will follow 78 Very Low Birth Weight (VLBW) infants previously enrolled in a R21 grant through the age of 4 years. The data gathered over 6 weeks of the NICU stay includes multiple factors that potentially could alter the gut micro biome, such as prenatal and postnatal events and illnesses, amount of human milk received, weekly means of cytokines, chemokine's, growth factors and secretory Immunoglobulin A in the milk, and weekly levels of fecal calprotectin. Stool samples have been preserved for analysis of the micro biome in the current study. Micro biome species and diversities will be measured in the laboratory of Dr. Jack Gilbert at Argonne National Lab using state of the science deep sequencing and amplification of microbial sRNA genes. The micro biome will again be measured in stool samples from these children at the ages of 2 and 4 years. Relationship between the pre and postnatal factors, human milk volume and immunobiology, fecal calprotectin levels and the very early micro biome will be analyzed. The predictive power of the VLBW infant gut micro biome for determining later childhood micro biomes will be analyzed prospectively. The relationships between micro biomes across time and later growth, development and health will be determined. VLBW infants are at risk for both early and later health effects, and the role of the micro biome in these effects will be measured for the first tim in this prospective study.
描述(由申请人提供): 该项目将跟踪78名极低出生体重(VLBW)婴儿,这些婴儿以前参加了R21补助金,直到4岁。在NICU停留的6周内收集的数据包括可能改变肠道微生物组的多种因素,例如产前和产后事件和疾病,接受的人乳量,乳汁中细胞因子、趋化因子、生长因子和分泌性免疫球蛋白A的每周平均值,以及粪便钙卫蛋白的每周水平。在本研究中,保存粪便样本用于微生物组分析。将在阿贡国家实验室的Jack吉尔伯特博士实验室中使用微生物sRNA基因的科学深度测序和扩增来测量微生物群落物种和多样性。将在这些儿童2岁和4岁时的粪便样本中再次测量微生物组。将分析产前和产后因素、母乳量和免疫生物学、粪便钙卫蛋白水平和极早期微生物组之间的关系。将前瞻性分析极低出生体重婴儿肠道微生物组确定儿童后期微生物组的预测能力。将确定微生物群之间的关系,随着时间的推移和以后的生长,发育和健康。极低出生体重婴儿在早期和后期都有健康影响的风险,在这项前瞻性研究中,将首次测量微生物组在这些影响中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maureen Edith Groer其他文献
Maureen Edith Groer的其他文献
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{{ truncateString('Maureen Edith Groer', 18)}}的其他基金
Chronic Toxoplasma gondii, Pregnancy reactivation, and Perinatal Depression
慢性弓形虫、妊娠再激活和围产期抑郁
- 批准号:
10164827 - 财政年份:2017
- 资助金额:
$ 56.41万 - 项目类别:
Chronic Toxoplasma gondii, Pregnancy reactivation, and Perinatal Depression
慢性弓形虫、妊娠再激活和围产期抑郁
- 批准号:
9382334 - 财政年份:2017
- 资助金额:
$ 56.41万 - 项目类别:
The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of Age
早产儿微生物组:2 岁和 4 岁时的生物学、行为和健康结果
- 批准号:
9237123 - 财政年份:2015
- 资助金额:
$ 56.41万 - 项目类别:
The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of Age
早产儿微生物组:2 岁和 4 岁时的生物学、行为和健康结果
- 批准号:
9066791 - 财政年份:2015
- 资助金额:
$ 56.41万 - 项目类别:
The association between preterm milk immunobiology and infant health
早产儿乳汁免疫生物学与婴儿健康之间的关联
- 批准号:
8305914 - 财政年份:2012
- 资助金额:
$ 56.41万 - 项目类别:
The association between preterm milk immunobiology and infant health
早产儿乳汁免疫生物学与婴儿健康之间的关联
- 批准号:
8440286 - 财政年份:2012
- 资助金额:
$ 56.41万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7811071 - 财政年份:2009
- 资助金额:
$ 56.41万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7373849 - 财政年份:2001
- 资助金额:
$ 56.41万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7496121 - 财政年份:2001
- 资助金额:
$ 56.41万 - 项目类别:
Influence of Lactation on Postpartum Stress and Immunity
哺乳对产后压力和免疫力的影响
- 批准号:
7847448 - 财政年份:2001
- 资助金额:
$ 56.41万 - 项目类别:
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