Blood Group Antigen Recognition by Group A Streptococcus Mediates Host Colonisation

A组链球菌（GAS）每年在全球造成约7亿例局部感染和60万例侵袭性感染。某些细菌已被证明可以识别宿主细胞上的糖（称为聚糖）。该项目将研究GAS如何使用宿主细胞表面的糖来引发疾病，并确定宿主细胞上存在的糖类型的差异是否会改变GAS引发感染的能力。

Group A streptococcus (GAS) is responsible for approximately 700 million cases of localised infection and 600,000 cases of invasive infection globally each year. Certain bacteria have been shown to recognise sugars (known as glycans) on host cells. This project will look at how GAS use sugars at the surface of host cells to initiate disease, and determine if differences in the types of sugars present on host cells alter the ability of GAS to initiate infection.