Blood Group Antigen Recognition by Group A Streptococcus Mediates Host Colonisation

A 族链球菌对血型抗原的识别介导宿主定植

• 批准号: nhmrc : 1143266
• 负责人: Dr Martina Sanderson-Smith
• 金额: $ 31.83万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/blood-group-antigen-host-colonisation/1319911
• 关键词: Blood; Group; Antigen; Recognition; Streptococcus

Group A streptococcus (GAS) is responsible for approximately 700 million cases of localised infection and 600,000 cases of invasive infection globally each year. Certain bacteria have been shown to recognise sugars (known as glycans) on host cells. This project will look at how GAS use sugars at the surface of host cells to initiate disease, and determine if differences in the types of sugars present on host cells alter the ability of GAS to initiate infection.

A组链球菌（GAS）每年在全球造成约7亿例局部感染和60万例侵袭性感染。某些细菌已被证明可以识别宿主细胞上的糖（称为聚糖）。该项目将研究GAS如何使用宿主细胞表面的糖来引发疾病，并确定宿主细胞上存在的糖类型的差异是否会改变GAS引发感染的能力。