Blood Group Antigen Recognition by Group A Streptococcus Mediates Host Colonisation

全球每年约有7亿局部感染病例和60万侵袭性感染病例是由A群链球菌（GAS）造成的。某些细菌已经被证明可以识别宿主细胞上的糖（被称为聚糖）。该项目将研究GAS如何利用宿主细胞表面的糖来引发疾病，并确定宿主细胞上存在的糖类型的差异是否会改变GAS引发感染的能力。

Group A streptococcus (GAS) is responsible for approximately 700 million cases of localised infection and 600,000 cases of invasive infection globally each year. Certain bacteria have been shown to recognise sugars (known as glycans) on host cells. This project will look at how GAS use sugars at the surface of host cells to initiate disease, and determine if differences in the types of sugars present on host cells alter the ability of GAS to initiate infection.