Body composition changes in cardiac cachexia: pathophysiology, quantification and approaches to therapy

心脏恶病质的身体成分变化：病理生理学、量化和治疗方法

• 批准号: nhmrc : 219143
• 负责人: Dr John Power
• 金额: $ 8万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/body-composition-changes-approaches-therapy/95896
• 关键词: Body; composition; changes; cardiac; cachexia

Cachexia is weight loss and weakness caused by disease, or as a side effect of illness. Congestive heart failure is a common cardiovascular condition that is accompanied by high mortality (up to 50% over 2 years) and considerable suffering. People with congestive heart failure often develop cachexia. This project will explore the mechanisms responsible for the development of cachexia using an animal model of cardiac cachexia that the researchers have developed. It will be complemented by an examination of the effects of exercise on measures of cachexia in patients with congestive heart failure. The researchers believe that this study will supply valuable new information about the development of cachexia and lead to new therapies for this syndrome.

恶病质是由疾病引起的体重减轻和虚弱，或作为疾病的副作用。充血性心力衰竭是一种常见的心血管疾病，伴随着高死亡率(两年内高达50%)和相当大的痛苦。充血性心力衰竭患者通常会出现恶病质。这个项目将使用研究人员开发的心脏恶病质动物模型来探索恶病质发生的机制。此外，还将研究运动对充血性心力衰竭患者恶病质指标的影响。研究人员相信，这项研究将为恶病质的发展提供有价值的新信息，并导致治疗这种综合征的新方法。