Body composition changes in cardiac cachexia: pathophysiology, quantification and approaches to therapy

恶病质是由疾病引起的体重减轻和虚弱，或作为疾病的副作用。充血性心力衰竭是一种常见的心血管疾病，伴随着高死亡率（2年内高达50%）和相当大的痛苦。患有充血性心力衰竭的人经常会出现恶病质。该项目将利用研究人员开发的心脏恶病质动物模型，探索恶病质形成的机制。它将通过检查运动对充血性心力衰竭患者恶病质测量的影响来补充。研究人员认为，这项研究将为恶病质的发展提供有价值的新信息，并为该综合征提供新的治疗方法。

Cachexia is weight loss and weakness caused by disease, or as a side effect of illness. Congestive heart failure is a common cardiovascular condition that is accompanied by high mortality (up to 50% over 2 years) and considerable suffering. People with congestive heart failure often develop cachexia. This project will explore the mechanisms responsible for the development of cachexia using an animal model of cardiac cachexia that the researchers have developed. It will be complemented by an examination of the effects of exercise on measures of cachexia in patients with congestive heart failure. The researchers believe that this study will supply valuable new information about the development of cachexia and lead to new therapies for this syndrome.