Mechanically-restricted percutaneous gene therapeutic solutions for heart failure.

我们开发了一种新的系统，用于将专门的基因局部递送到心脏，以改善衰竭心脏的收缩性和功能。由于毒性、清除或摄取的原因，许多基因需要直接递送到靶区域而不溢出到体循环。我们的系统通过隔离靶器官的局部循环并以最小的全身损失和改善的递送和摄取效率直接递送药剂来解决这些问题，同时最大限度地减少潜在的危险和毒性全身作用。

We have developed a novel system for the localized delivery of specialised genes to the heart in order to improve contractility and function of a failing heart. Many genes, for reasons of toxicity, clearance, or uptake, require direct delivery to the target region without spillover to the systemic circulation. Our system addresses these issues by isolating the local circulation of the target organ and directly delivering the agent with minimal systemic loss and improved delivery and uptake efficiency, while minimizing potentially dangerous and toxic systemic effects.